Human Recombinant DDC protein, His Tag (V2LY-0526-LY3616)

Name: Human Recombinant DDC protein, His Tag
SKU: V2LY-0526-LY3616
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant DDC protein, His Tag consist of Amino Acid: 1-480 and predicts a molecular mass of 55 kDa.

Molecule Mass

55 kDa

Verified

HPLC

Sequence

Amino Acid: 1-480

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥85% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Dopa Decarboxylase

Function

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Biological Process

Aminergic neurotransmitter loading into synaptic vesicle Source: Ensembl
Catecholamine biosynthetic process Source: Reactome
Catecholamine metabolic process Source: GO_Central
Cellular amino acid metabolic process Source: InterPro
Cellular response to alkaloid Source: Ensembl
Cellular response to drug Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Circadian rhythm Source: Ensembl
Dopamine biosynthetic process Source: UniProtKB-UniPathway
Indolalkylamine biosynthetic process Source: Reactome
Isoquinoline alkaloid metabolic process Source: Ensembl
Multicellular organism aging Source: Ensembl
Phytoalexin metabolic process Source: Ensembl
Response to pyrethroid Source: Ensembl
Serotonin biosynthetic process Source: GO_Central

Cellular Location

Cytosol; Extracellular exosome; Axon; Cytoplasm; Neuronal cell body; Synaptic vesicle

Involvement in disease

Aromatic L-amino-acid decarboxylase deficiency (AADCD):
An inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.

Mpekoulis, G., Frakolaki, E., Taka, S., Ioannidis, A., Vassiliou, A. G., Kalliampakou, K. I., ... & Vassilaki, N. (2021). Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform. PloS one, 16(6), e0253458.

Papatsirou, M., Adamopoulos, P. G., Artemaki, P. I., Georganti, V. P., Scorilas, A., Vassilacopoulou, D., & Kontos, C. K. (2021). Next-generation sequencing reveals alternative L-DOPA decarboxylase (DDC) splice variants bearing novel exons, in human hepatocellular and lung cancer cells. Gene, 768, 145262.

Chalatsa, I., Arvanitis, N., Arvanitis, D., Tsakou, A. C., Kalantzis, E. D., Vassiliou, A. G., ... & Vassilacopoulou, D. (2020). Human L-Dopa decarboxylase interaction with annexin V and expression during apoptosis. Biochimie, 177, 78-86.

Artemaki, P. I., Papatsirou, M., Boti, M. A., Adamopoulos, P. G., Christodoulou, S., Vassilacopoulou, D., ... & Kontos, C. K. (2020). Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression. International journal of molecular sciences, 21(22), 8568.

Stefi, A. L., Vassilacopoulou, D., & Christodoulakis, N. S. (2019). Environmentally stressed summer leaves of the seasonally dimorphic Phlomis fruticosa and the relief through the L-Dopa decarboxylase (DDC). Flora, 251, 11-19.

Frakolaki, E., Kalliampakou, K. I., Kaimou, P., Moraiti, M., Kolaitis, N., Boleti, H., ... & Vassilaki, N. (2019). Emerging role of l-Dopa decarboxylase in flaviviridae virus infections. Cells, 8(8), 837.

Vassiliou, A. G., Siaterli, M. Z., Frakolaki, E., Gkogkosi, P., Paspaltsis, I., Sklaviadis, T., ... & Vassilaki, N. (2019). L-Dopa decarboxylase interaction with the major signaling regulator ΡΙ3Κ in tissues and cells of neural and peripheral origin. Biochimie, 160, 76-87.

Adamopoulos, P. G., Tsiakanikas, P., Kontos, C. K., Panagiotou, A., Vassilacopoulou, D., & Scorilas, A. (2019). Identification of novel alternative splice variants of the human L-DOPA decarboxylase (DDC) gene in human cancer cells, using high-throughput sequencing approaches. Gene, 719, 144075.

Wang, K., Ren, Q., Shen, X. L., Li, B., Du, J., Yu, X. D., & Du, Z. Q. (2019). Molecular characterization and expression analysis of dopa decarboxylase involved in the antibacterial innate immunity of the freshwater crayfish, Procambarus clarkii. Fish & Shellfish Immunology, 91, 19-28.

Kow, R. L., Sikkema, C., Wheeler, J. M., Wilkinson, C. W., & Kraemer, B. C. (2018). DOPA decarboxylase modulates tau toxicity. Biological psychiatry, 83(5), 438-446.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant DDC protein, His Tag (CAT#: V2LY-0526-LY8208)

DDC Matched Antibody Pair (330) (CAT#: APMAB-330LY)

Antibody Pairs

DDC Matched Antibody Pair (330) (CAT#: APMAB-330LY)

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Mouse Recombinant DDC protein, His Tag (CAT#: V2LY-0526-LY8208)

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Isotype control

For research use only. Not intended for any clinical use.

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