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DGKA

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
Full Name
Diacylglycerol Kinase Alpha
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:2175712, PubMed:15544348).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:2175712, PubMed:15544348).

Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (PubMed:15544348).

Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129).
Biological Process
Diacylglycerol metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: BHF-UCL
Intracellular signal transduction Source: GO_Central
Lipid phosphorylation Source: UniProtKB
Phosphatidic acid biosynthetic process Source: UniProtKB
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Cellular Location
Cytosol
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Anti-DGKA antibodies

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Rabbit Anti-DGKA Recombinant Antibody (EG951) (CBMAB-EN1130-LY)

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Target: DGKA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG951
Application*: IP, F, WB
Datasheet SDS

Mouse Anti-DGKA Recombinant Antibody (6B3) (CBMAB-D0774-YC)

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Target: DGKA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6B3
Application*: IP, WB
Datasheet SDS

Mouse Anti-DGKA Recombinant Antibody (4H10) (CBMAB-D0772-YC)

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Target: DGKA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Dog, Human, Monkey
Clone: 4H10
Application*: IF, WB
Datasheet SDS

Mouse Anti-DGKA Recombinant Antibody (D0768) (CBMAB-D0768-YC)

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Target: DGKA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D0768
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DGKA Recombinant Antibody (7B6) (V2LY-0425-LY241)

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Target: DGKA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7B6
Application*: IH, WB
Datasheet SDS

Mouse Anti-DGKA Recombinant Antibody (4A11) (V2LY-0425-LY238)

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Target: DGKA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A11
Application*: F, P, WB
Datasheet SDS

Mouse Anti-DGKA Recombinant Antibody (3G7) (V2LY-0425-LY237)

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Target: DGKA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Dog
Clone: 3G7
Application*: WB, F
Datasheet SDS

Mouse Anti-DGKA Recombinant Antibody (2B7) (V2LY-0425-LY236)

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Target: DGKA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B7
Application*: E, P, PLA
Datasheet SDS

DGKA Matched Antibody Pair (338) (APMAB-338LY)

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Target: DGKA
Specificity: Human
Datasheet SDS

DGKA Matched Antibody Pair (337) (APMAB-337LY)

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Target: DGKA
Specificity: Human
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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