DPYD

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Full Name
Dihydropyrimidine Dehydrogenase
Function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Biological Process
Beta-alanine biosynthetic process Source: UniProtKB-UniPathway
Purine nucleobase catabolic process Source: UniProtKB
Pyrimidine nucleobase catabolic process Source: UniProtKB
Thymidine catabolic process Source: UniProtKB
Thymine catabolic process Source: UniProtKB
Uracil catabolic process Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Dihydropyrimidine dehydrogenase deficiency (DPYDD):
A metabolic disorder with large phenotypic variability, ranging from no symptoms to a convulsive disorder with motor and mental retardation. It is characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil.
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Anti-DPYD antibodies

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Mouse Anti-DPYD Recombinant Antibody (10C16) (V2LY-0425-LY891)

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Target: DPYD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Dog, Cattle, Pig
Clone: 10C16
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DPYD Recombinant Antibody (D1643) (V2LY-0425-LY890)

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Target: DPYD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cattle, Pig
Clone: D1643
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-DPYD Recombinant Antibody (D1642) (V2LY-0425-LY889)

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Target: DPYD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1642
Application*: WB, P
Datasheet SDS

Mouse Anti-DPYD Recombinant Antibody (CBYCD-397) (V2LY-0425-LY888)

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Target: DPYD
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYCD-397
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DPYD Recombinant Antibody (7D4) (V2LY-0425-LY887)

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Target: DPYD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7D4
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-DPYD Recombinant Antibody (10C16) (CBMAB-D1645-YC)

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Target: DPYD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10C16
Application*: E, IC, WB
Datasheet SDS

Rabbit Anti-DPYD Recombinant Antibody (D35A8) (CBMAB-D1643-YC)

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Target: DPYD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Dog
Clone: D35A8
Application*: WB
Datasheet SDS

Rabbit Anti-DPYD Recombinant Antibody (10g83) (CBMAB-D1642-YC)

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Target: DPYD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10g83
Application*: WB
Datasheet SDS

Mouse Anti-DPYD Recombinant Antibody (CBYCD-397) (CBMAB-D1641-YC)

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Target: DPYD
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-397
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-DPYD Recombinant Antibody (7D4) (CBMAB-D1640-YC)

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Target: DPYD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7D4
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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