DPYSL3

DPYSL3 (Dihydropyrimidinase Like 3) is a Protein Coding gene. Diseases associated with DPYSL3 include Prostate Lymphoma and Hypertensive Encephalopathy. Among its related pathways are Semaphorin interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein binding. An important paralog of this gene is CRMP1.

Full Name

dihydropyrimidinase-like 3

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).

Biological Process

Actin crosslink formation Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Cellular response to cytokine stimulus Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of neuron projection development Source: UniProtKB
Neuron development Source: Ensembl
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of neuron projection development Source: UniProtKB
Response to axon injury Source: UniProtKB

Cellular Location

Cytoplasm; Growth cone. Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.

PTM

Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.