DSCAML1

The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type.

Full Name

Down syndrome cell adhesion molecule like 1

Research Area

Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658).

Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity).

Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

Biological Process

Axon guidance Source: GO_Central
Axonogenesis Source: UniProtKB
Brain development Source: UniProtKB
Cell fate determination Source: UniProtKB
Central nervous system development Source: UniProtKB
Dendrite self-avoidance Source: GO_Central
Dorsal/ventral pattern formation Source: UniProtKB
Embryonic skeletal system morphogenesis Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB

Cellular Location

Cell membrane; Synapse

Topology

Extracellular: 19-1591
Helical: 1592-1612
Cytoplasmic: 1613-2053