Mouse Anti-DSCAML1 Recombinant Antibody (6B10) (CBMAB-D1728-YC)

Name: Mouse Anti-DSCAML1 Recombinant Antibody (6B10)
SKU: CBMAB-D1728-YC
Rating: 5 (1 reviews)

See all DSCAML1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6B10

Application

ELISA, WB

Immunogen

DSCAML1 (NP_065744.2, 1922 a.a. ~ 2008 a.a) partial recombinant protein with GST tag. The immunogen sequence: SEPGICRFTA SPPKPQDADR GKNVAVPIPH RANKSDYCNL PLYAKSEAFF RKADGREPCP VVPPREASIR NLARTYHTQA RHLTLDP

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Down syndrome cell adhesion molecule like 1

Introduction

DSCAML1 is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type.

Entrez Gene ID

57453

UniProt ID

Q8TD84

Alternative Names

DS Cell Adhesion Molecule Like 1; Down Syndrome Cell Adhesion Molecule 2; DSCAM2; Down Syndrome Cell Adhesion Molecule-Like Protein 1; Downs Syndrome Cell Adhesion Molecule Like 1; Down Syndrome Cell Adhesion Molecule Like 1; DSCAM-Like 1; KIAA1132;

Research Area

Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658).

Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity).

Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

Biological Process

Axon guidance Source: GO_Central
Axonogenesis Source: UniProtKB
Brain development Source: UniProtKB
Cell fate determination Source: UniProtKB
Central nervous system development Source: UniProtKB
Dendrite self-avoidance Source: GO_Central
Dorsal/ventral pattern formation Source: UniProtKB
Embryonic skeletal system morphogenesis Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB

Cellular Location

Cell membrane; Synapse

Topology

Extracellular: 19-1591
Helical: 1592-1612
Cytoplasmic: 1613-2053

Wang, K., Kang, Z., Jiang, E., Yan, H., Zhu, H., Liu, J., ... & Pan, C. (2020). Genetic effects of DSCAML1 identified in genome-wide association study revealing strong associations with litter size and semen quality in goat (Capra hircus). Theriogenology, 146, 20-25.

Ramirez, A. D., Roberts, R. L., Harmon, K. E., Schoppik, D., Sharma, A., Kuang, C., ... & Schier, A. F. (2019). Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function. Journal of Neuroscience.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-DSCAML1 Recombinant Antibody (6B10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DSCAML1 Recombinant Antibody (6B10) (CAT#: V2LY-0425-LY960)

Related Products

Mouse Anti-DSCAML1 Recombinant Antibody (6B10) (CAT#: V2LY-0425-LY960)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry