DUSP1

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq]

dual specificity phosphatase 1

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

Cell cycle Source: UniProtKB-KW
Cellular response to chemokine Source: BHF-UCL
Cellular response to hormone stimulus Source: Ensembl
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: UniProtKB
Intracellular signal transduction Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell adhesion Source: BHF-UCL
Negative regulation of DNA biosynthetic process Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of MAPK cascade Source: UniProtKB
Negative regulation of MAP kinase activity Source: UniProtKB
Negative regulation of meiotic cell cycle Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Negative regulation of p38MAPK cascade Source: BHF-UCL
Peptidyl-serine dephosphorylation Source: UniProtKB
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Protein dephosphorylation Source: GO_Central
Regulation of cell cycle Source: UniProtKB
Regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
Response to calcium ion Source: Ensembl
Response to cAMP Source: Ensembl
Response to estradiol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to light stimulus Source: Ensembl
Response to retinoic acid Source: Ensembl
Response to testosterone Source: Ensembl

Nucleus

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.