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Mouse Anti-DUSP1 Recombinant Antibody (4H7) (CBMAB-D1874-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dual Specificity Phosphatase 1 (DUSP1). The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all DUSP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
dual specificity phosphatase 1
Introduction
DUSP1 is a phosphatase with dual specificity for tyrosine and threonine. The protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, The protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Entrez Gene ID
1843
UniProt ID
P28562
Alternative Names
Dual Specificity Phosphatase 1; Mitogen-Activated Protein Kinase Phosphatase 1; Dual Specificity Protein Phosphatase HVH1; Protein-Tyrosine Phosphatase CL100; MAP Kinase Phosphatase 1; PTPN10; CL100; MKP-1; MKP1;
Research Area
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Biological Process
Cell cycle Source: UniProtKB-KW
Cellular response to chemokine Source: BHF-UCL
Cellular response to hormone stimulus Source: Ensembl
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: UniProtKB
Intracellular signal transduction Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell adhesion Source: BHF-UCL
Negative regulation of DNA biosynthetic process Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of MAPK cascade Source: UniProtKB
Negative regulation of MAP kinase activity Source: UniProtKB
Negative regulation of meiotic cell cycle Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Negative regulation of p38MAPK cascade Source: BHF-UCL
Peptidyl-serine dephosphorylation Source: UniProtKB
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Protein dephosphorylation Source: GO_Central
Regulation of cell cycle Source: UniProtKB
Regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
Response to calcium ion Source: Ensembl
Response to cAMP Source: Ensembl
Response to estradiol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to light stimulus Source: Ensembl
Response to retinoic acid Source: Ensembl
Response to testosterone Source: Ensembl
Cellular Location
Nucleus
PTM
Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.

Bermúdez-Muñoz, J. M., Celaya, A. M., García-Mato, Á., Muñoz-Espín, D., Rodríguez-de la Rosa, L., Serrano, M., & Varela-Nieto, I. (2021). Dual-specificity phosphatase 1 (DUSP1) has a central role in redox homeostasis and inflammation in the mouse cochlea. Antioxidants, 10(9), 1351.

Maekawa, A., Sawaji, Y., Endo, K., Kusakabe, T., Konishi, T., Tateiwa, T., ... & Yamamoto, K. (2021). Prostaglandin E2 induces dual-specificity phosphatase-1, thereby attenuating inflammatory genes expression in human osteoarthritic synovial fibroblasts. Prostaglandins & Other Lipid Mediators, 154, 106550.

Pan, J., Lin, M., Xu, Z., Xu, M., Zhang, J., Weng, Z., ... & Lin, X. (2021). CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1. Carcinogenesis, 42(11), 1399-1409.

Hoppstädter, J., & Ammit, A. J. (2019). Role of dual-specificity phosphatase 1 in glucocorticoid-driven anti-inflammatory responses. Frontiers in Immunology, 10, 1446.

Martínez-Martínez, D., Soto, A., Gil-Araujo, B., Gallego, B., Chiloeches, A., & Lasa, M. (2019). Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin. Food and chemical toxicology, 124, 273-279.

Fu, X. H., Chen, C. Z., Li, S., Han, D. X., Wang, Y. J., Yuan, B., ... & Jiang, H. (2019). Dual-specificity phosphatase 1 regulates cell cycle progression and apoptosis in cumulus cells by affecting mitochondrial function, oxidative stress, and autophagy. American Journal of Physiology-Cell Physiology, 317(6), C1183-C1193.

Gumpena, R., Lountos, G. T., Raran‐Kurussi, S., Tropea, J. E., Cherry, S., & Waugh, D. S. (2018). Crystal structure of the human dual specificity phosphatase 1 catalytic domain. Protein Science, 27(2), 561-567.

Tuglu, M. M., Bostanabad, S. Y., Ozyon, G., Dalkiliç, B., & Gurdal, H. (2018). The role of dual‑specificity phosphatase 1 and protein phosphatase 1 in β2‑adrenergic receptor‑mediated inhibition of extracellular signal regulated kinase 1/2 in triple negative breast cancer cell lines. Molecular Medicine Reports, 17(1), 2033-2043.

Peng, H. Z., Yun, Z., Wang, W., & Ma, B. A. (2017). Dual specificity phosphatase 1 has a protective role in osteoarthritis fibroblast‑like synoviocytes via inhibition of the MAPK signaling pathway. Molecular Medicine Reports, 16(6), 8441-8447.

Zhao, Y., Wang, S., Chu, Z., Dang, Y., Zhu, J., & Su, X. (2017). MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1). Brain research, 1669, 55-62.

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For research use only. Not intended for any clinical use.

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