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Mouse Anti-DUSP1 Recombinant Antibody (CBFYM-1073) (CBMAB-M1226-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1073
Antibody Isotype
IgG2b
Application
WB, IP

Basic Information

Immunogen
Recombinant human protein purified from E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, 0.15 M NaCl, 0.01% BSA
Preservative
0.03% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Entrez Gene ID
1843
UniProt ID
P28562
Alternative Names
Dual Specificity Phosphatase 1; Mitogen-Activated Protein Kinase Phosphatase 1; Dual Specificity Protein Phosphatase HVH1; Protein-Tyrosine Phosphatase CL100; MAP Kinase Phosphatase 1; PTPN10; CL100; MKP-1; MKP1
Research Area
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Biological Process
Cell cycle Source: UniProtKB-KW
Cellular response to chemokine Source: BHF-UCL
Cellular response to hormone stimulus Source: Ensembl
Endoderm formation Source: GO_Central
Inactivation of MAPK activity Source: UniProtKB
Intracellular signal transduction Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell adhesion Source: BHF-UCL
Negative regulation of DNA biosynthetic process Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of MAPK cascade Source: UniProtKB
Negative regulation of MAP kinase activity Source: UniProtKB
Negative regulation of meiotic cell cycle Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Negative regulation of p38MAPK cascade Source: BHF-UCL
Peptidyl-serine dephosphorylation Source: UniProtKB
Peptidyl-threonine dephosphorylation Source: UniProtKB
Peptidyl-tyrosine dephosphorylation Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Protein dephosphorylation Source: GO_Central
Regulation of cell cycle Source: UniProtKB
Regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
Response to calcium ion Source: Ensembl
Response to cAMP Source: Ensembl
Response to estradiol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to light stimulus Source: Ensembl
Response to retinoic acid Source: Ensembl
Response to testosterone Source: Ensembl
Cellular Location
Nucleus
PTM
Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
More Infomation

Bermúdez-Muñoz, J. M., Celaya, A. M., García-Mato, Á., Muñoz-Espín, D., Rodríguez-de la Rosa, L., Serrano, M., & Varela-Nieto, I. (2021). Dual-specificity phosphatase 1 (DUSP1) has a central role in redox homeostasis and inflammation in the mouse cochlea. Antioxidants, 10(9), 1351.

Maekawa, A., Sawaji, Y., Endo, K., Kusakabe, T., Konishi, T., Tateiwa, T., ... & Yamamoto, K. (2021). Prostaglandin E2 induces dual-specificity phosphatase-1, thereby attenuating inflammatory genes expression in human osteoarthritic synovial fibroblasts. Prostaglandins & Other Lipid Mediators, 154, 106550.

Pan, J., Lin, M., Xu, Z., Xu, M., Zhang, J., Weng, Z., ... & Lin, X. (2021). CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1. Carcinogenesis, 42(11), 1399-1409.

Hoppstädter, J., & Ammit, A. J. (2019). Role of dual-specificity phosphatase 1 in glucocorticoid-driven anti-inflammatory responses. Frontiers in Immunology, 10, 1446.

Martínez-Martínez, D., Soto, A., Gil-Araujo, B., Gallego, B., Chiloeches, A., & Lasa, M. (2019). Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin. Food and chemical toxicology, 124, 273-279.

Fu, X. H., Chen, C. Z., Li, S., Han, D. X., Wang, Y. J., Yuan, B., ... & Jiang, H. (2019). Dual-specificity phosphatase 1 regulates cell cycle progression and apoptosis in cumulus cells by affecting mitochondrial function, oxidative stress, and autophagy. American Journal of Physiology-Cell Physiology, 317(6), C1183-C1193.

Gumpena, R., Lountos, G. T., Raran‐Kurussi, S., Tropea, J. E., Cherry, S., & Waugh, D. S. (2018). Crystal structure of the human dual specificity phosphatase 1 catalytic domain. Protein Science, 27(2), 561-567.

Tuglu, M. M., Bostanabad, S. Y., Ozyon, G., Dalkiliç, B., & Gurdal, H. (2018). The role of dual‑specificity phosphatase 1 and protein phosphatase 1 in β2‑adrenergic receptor‑mediated inhibition of extracellular signal regulated kinase 1/2 in triple negative breast cancer cell lines. Molecular Medicine Reports, 17(1), 2033-2043.

Peng, H. Z., Yun, Z., Wang, W., & Ma, B. A. (2017). Dual specificity phosphatase 1 has a protective role in osteoarthritis fibroblast‑like synoviocytes via inhibition of the MAPK signaling pathway. Molecular Medicine Reports, 16(6), 8441-8447.

Zhao, Y., Wang, S., Chu, Z., Dang, Y., Zhu, J., & Su, X. (2017). MicroRNA-101 in the ventrolateral orbital cortex (VLO) modulates depressive-like behaviors in rats and targets dual-specificity phosphatase 1 (DUSP1). Brain research, 1669, 55-62.

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For research use only. Not intended for any clinical use.

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