DUSP10

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Full Name

Dual Specificity Phosphatase 10

Research Area

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.

Biological Process

Dephosphorylation Source: UniProtKB
Inactivation of MAPK activity Source: UniProtKB
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of epithelial cell migration Source: BHF-UCL
Negative regulation of epithelial cell proliferation Source: BHF-UCL
Negative regulation of epithelium regeneration Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Negative regulation of JNK cascade Source: BHF-UCL
Negative regulation of JUN kinase activity Source: BHF-UCL
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of p38MAPK cascade Source: BHF-UCL
Negative regulation of protein kinase activity by regulation of protein phosphorylation Source: Ensembl
Negative regulation of respiratory burst involved in inflammatory response Source: Ensembl
Oligodendrocyte differentiation Source: Ensembl
Peptidyl-threonine dephosphorylation Source: BHF-UCL
Peptidyl-tyrosine dephosphorylation Source: GO_Central
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: BHF-UCL
Positive regulation of regulatory T cell differentiation Source: BHF-UCL
Protein dephosphorylation Source: UniProtKB
Regulation of adaptive immune response Source: Ensembl
Regulation of brown fat cell differentiation Source: Ensembl
Response to lipopolysaccharide Source: Ensembl

Cellular Location

Nucleus; Cytoplasm