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Mouse Anti-DUSP10 Recombinant Antibody (1F2) (CBMAB-D1877-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dual Specificity Phosphatase 10 (DUSP10). The antibody can be used for immunoassay techniques, such as WB.
See all DUSP10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F2
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 180-482 of human DUSP10(NP_009138) produced in E. coli.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dual Specificity Phosphatase 10
Introduction
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK.
Entrez Gene ID
11221
UniProt ID
Q9Y6W6
Alternative Names
Dual Specificity Phosphatase 10; Mitogen-Activated Protein Kinase Phosphatase 5; MKP-5; MKP5; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Protein Phosphatase 10;
Research Area
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.
Biological Process
Dephosphorylation Source: UniProtKB
Inactivation of MAPK activity Source: UniProtKB
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of epithelial cell migration Source: BHF-UCL
Negative regulation of epithelial cell proliferation Source: BHF-UCL
Negative regulation of epithelium regeneration Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Negative regulation of JNK cascade Source: BHF-UCL
Negative regulation of JUN kinase activity Source: BHF-UCL
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of p38MAPK cascade Source: BHF-UCL
Negative regulation of protein kinase activity by regulation of protein phosphorylation Source: Ensembl
Negative regulation of respiratory burst involved in inflammatory response Source: Ensembl
Oligodendrocyte differentiation Source: Ensembl
Peptidyl-threonine dephosphorylation Source: BHF-UCL
Peptidyl-tyrosine dephosphorylation Source: GO_Central
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: BHF-UCL
Positive regulation of regulatory T cell differentiation Source: BHF-UCL
Protein dephosphorylation Source: UniProtKB
Regulation of adaptive immune response Source: Ensembl
Regulation of brown fat cell differentiation Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Cellular Location
Nucleus; Cytoplasm

Zhou, W., Xu, Y., Zhang, J., Zhang, P., Yao, Z., Yan, Z., ... & Liu, Y. (2022). MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma. Leukemia, 1-9.

Foray, A. P., Candon, S., Hildebrand, S., Marquet, C., Valette, F., Pecquet, C., ... & Chatenoud, L. (2021). De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes. Proceedings of the National Academy of Sciences, 118(47).

Chen, H., Yao, X., Di, X., Zhang, Y., Zhu, H., Liu, S., ... & Sun, X. (2020). MiR-450a-5p inhibits autophagy and enhances radiosensitivity by targeting dual-specificity phosphatase 10 in esophageal squamous cell carcinoma. Cancer Letters, 483, 114-126.

Flem-Karlsen, K., Tekle, C., Øyjord, T., Flørenes, V. A., Mælandsmo, G. M., Fodstad, Ø., & Nunes-Xavier, C. E. (2019). p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance. Scientific reports, 9(1), 1-9.

Jiménez-Martínez, M., Stamatakis, K., & Fresno, M. (2019). The dual-specificity phosphatase 10 (DUSP10): its role in cancer, inflammation, and immunity. International journal of molecular sciences, 20(7), 1626.

Xylourgidis, N., Min, K., Ahangari, F., Yu, G., Herazo-Maya, J. D., Karampitsakos, T., ... & Tzouvelekis, A. (2019). Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis. American Journal of Physiology-Lung Cellular and Molecular Physiology, 317(5), L678-L689.

Jiménez-Martínez, M., Ostalé, C. M., Van der Burg, L. R., Galán-Martínez, J., Hardwick, J. C., López-Pérez, R., ... & Fresno, M. (2019). DUSP10 is a regulator of YAP1 activity promoting cell proliferation and colorectal cancer progression. Cancers, 11(11), 1767.

Manley, G. C., Stokes, C. A., Marsh, E. K., Sabroe, I., & Parker, L. C. (2019). DUSP10 negatively regulates the inflammatory response to rhinovirus through interleukin-1β signaling. Journal of virology, 93(2), e01659-18.

Furuta, J., Ariyoshi, W., Okinaga, T., Takeuchi, J., Mitsugi, S., Tominaga, K., & Nishihara, T. (2017). High molecular weight hyaluronic acid regulates MMP13 expression in chondrocytes via DUSP10/MKP5. Journal of Orthopaedic Research, 35(2), 331-339.

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For research use only. Not intended for any clinical use.

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