DYRK1B

This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Full Name
Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B
Research Area
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).
Biological Process
Adipose tissue development Source: UniProtKB
Myoblast fusion Source: Ensembl
Peptidyl-serine phosphorylation Source: GO_Central
Peptidyl-threonine phosphorylation Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein autophosphorylation Source: InterPro
Protein phosphorylation Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Abdominal obesity-metabolic syndrome 3 (AOMS3):
A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes.
PTM
Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
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Anti-DYRK1B antibodies

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Rabbit Anti-DYRK1B Recombinant Antibody (D40D1) (CBMAB-D2019-YC)

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Target: DYRK1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D40D1
Application*: WB, IP
Datasheet SDS

Human Recombinant DYRK1B, Active protein, GST Tag (V2LY-0526-LY3663)

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Target: DYRK1B
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

Rabbit Anti-DYRK1B Recombinant Antibody (EG1015) (V2LY-0425-LY1156)

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Target: DYRK1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1015
Application*: WB, IP
Datasheet SDS

Mouse Anti-DYRK1B Recombinant Antibody (2E8) (V2LY-0425-LY1155)

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Target: DYRK1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2E8
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-DYRK1B Recombinant Antibody (D2019) (V2LY-0425-LY1154)

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Target: DYRK1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cattle
Clone: D2019
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DYRK1B Recombinant Antibody (CBYCD-464) (V2LY-0425-LY1153)

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Target: DYRK1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Pig
Clone: CBYCD-464
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-DYRK1B Recombinant Antibody (EG1015) (CBMAB-EN1198-LY)

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Target: DYRK1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1015
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS

Mouse Anti-DYRK1B Recombinant Antibody (2E8) (CBMAB-D2021-YC)

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Target: DYRK1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E8
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-DYRK1B Recombinant Antibody (CBYCD-464) (CBMAB-D2018-YC)

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Target: DYRK1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCD-464
Application*: E, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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