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E2F5

This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.

Full Name

E2F transcription factor 5

Research Area

Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

Biological Process

Cell projection organization Source: UniProtKB-KW
Regulation of cell cycle Source: InterPro
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

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Anti-E2F5 antibodies

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Mouse Anti-E2F5 Recombinant Antibody (CBFYE-0376) (V2LY-0425-LY1248)

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Target: E2F5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig

Clone: CBFYE-0376

Application*: WB, IP, IF, E

Mouse Anti-E2F5 Recombinant Antibody (E0678) (CBMAB-E0678-FY)

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Target: E2F5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig

Clone: E0678

Application*: WB, IP, IF, E, P

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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