EDC3

This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]
Full Name
Enhancer Of MRNA Decapping 3
Research Area
Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.
Biological Process
Deadenylation-independent decapping of nuclear-transcribed mRNA Source: GO_Central
P-body assembly Source: GO_Central
Cellular Location
P-body. Processing bodies (PB).
Involvement in disease
Mental retardation, autosomal recessive 50 (MRT50):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT50 patients show mild intellectual disability and microcephaly.
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Anti-EDC3 antibodies

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Mouse Anti-EDC3 Recombinant Antibody (CBFYE-0024) (V2LY-0425-LY1390)

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Target: EDC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0024
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EDC3 Recombinant Antibody (E0752) (V2LY-0425-LY1389)

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Target: EDC3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: E0752
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-EDC3 Recombinant Antibody (CBFYE-0024) (CBMAB-E0050-FY)

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Target: EDC3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0024
Application*: E, WB
Datasheet SDS

Rabbit Anti-EDC3 Recombinant Antibody (D2T7U) (CBMAB-E0752-FY)

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Target: EDC3
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: D2T7U
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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