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Rabbit Anti-EDC3 Recombinant Antibody (D2T7U) (CBMAB-E0752-FY)

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Basic Information

Host Animal
Rabbit
Clone
D2T7U
Application
WB, IP
Specificity
Human, Mouse, Rat, Monkey
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Enhancer Of MRNA Decapping 3
Introduction
This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability.
Entrez Gene ID
Human80153
Mouse353190
Rat315708
Monkey709182
UniProt ID
HumanQ96F86
MouseQ8K2D3
RatF1M7Z1
MonkeyQ4R8V9
Alternative Names
Enhancer Of MRNA Decapping 3; YjeF N-Terminal Domain-Containing Protein 2; LSM16 Homolog (EDC3, S. Cerevisiae); YjeF Domain-Containing Protein 1; YJEFN2; LSM16; YJDC; Enhancer Of MRNA Decapping 3 Homolog (S. Cerevisiae); Enhancer Of MRNA Decapping 3 Homolog
Research Area
Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.
Biological Process
Deadenylation-independent decapping of nuclear-transcribed mRNA Source: GO_Central
P-body assembly Source: GO_Central
Cellular Location
P-body. Processing bodies (PB).
Involvement in disease
Mental retardation, autosomal recessive 50 (MRT50):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT50 patients show mild intellectual disability and microcephaly.

Bearss, J. J., Padi, S. K., Singh, N., Cardo‐Vila, M., Song, J. H., Mouneimne, G., ... & Okumura, K. (2021). EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics. EMBO reports, 22(4), e50835.

Paquette, D. R., Tibble, R. W., Daifuku, T. S., & Gross, J. D. (2018). Control of mRNA decapping by autoinhibition. Nucleic Acids Research, 46(12), 6318-6329.

Charenton, C., & Graille, M. (2018). mRNA decapping: finding the right structures. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1762), 20180164.

Mugridge, J. S., Tibble, R. W., Ziemniak, M., Jemielity, J., & Gross, J. D. (2018). Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nature communications, 9(1), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-EDC3 Recombinant Antibody (CBFYE-0024) (CAT#: V2LY-0425-LY1390)

Mouse Anti-EDC3 Recombinant Antibody (CBFYE-0024) (CAT#: CBMAB-E0050-FY)

Mouse Anti-EDC3 Recombinant Antibody (E0752) (CAT#: V2LY-0425-LY1389)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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