ESRRA

The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Full Name
Estrogen Related Receptor Alpha
Research Area
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Biological Process
Cartilage development Source: Ensembl
Positive regulation of cellular response to insulin stimulus Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of cell population proliferation Source: Ensembl
Regulation of ossification Source: Ensembl
Regulation of osteoblast differentiation Source: Ensembl
Regulation of osteoclast differentiation Source: Ensembl
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estradiol Source: Ensembl
Cellular Location
Cytoplasm; Nucleus. Co-localizes to the cytoplasm only in presence of MAPK15.
PTM
Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.
Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
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Anti-ESRRA antibodies

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Mouse Anti-ESRRA Recombinant Antibody (CAP725) (CBMAB-AP2153LY)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CAP725
Application*: IP, WB
Datasheet SDS

Mouse Anti-ESRRA Recombinant Antibody (CBFYE-1302) (CBMAB-E1903-FY)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-1302
Application*: P, IH, IP, WB
Datasheet SDS

Mouse Anti-ESRRA Recombinant Antibody (CBFYE-1301) (CBMAB-E1901-FY)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-1301
Application*: IP, WB
Datasheet SDS

Mouse Anti-ESRRA Recombinant Antibody (CBFYE-1299) (CBMAB-E1898-FY)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYE-1299
Application*: E, WB, F
Datasheet SDS

Mouse Anti-ESRRA Recombinant Antibody (CBFYE-1300) (V2LY-0825-LY809)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-1300
Application*: IP, WB
Datasheet SDS

Rabbit Anti-ESRRA Recombinant Antibody (CBFYE-0264) (V2LY-0825-LY807)

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Target: ESRRA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYE-0264
Application*: IH, WB, IP, F
Datasheet SDS

Mouse Anti-ESRRA Recombinant Antibody (E1899) (V2LY-0825-LY806)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: E1899
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-ESRRA Recombinant Antibody (CBT4653) (V2LY-0625-LY615)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT4653
Application*: WB, F
Datasheet SDS

Mouse Anti-ESRRA Recombinant Antibody (CBT2518) (V2LY-0625-LY614)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2518
Application*: F
Datasheet SDS

Mouse Anti-ESRRA Monoclonal Antibody (1B10) (CBMAB-0356-YC)

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Target: ESRRA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B10
Application*: IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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