FDXR

This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene.

Full Name

Ferredoxin Reductase

Research Area

Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

Biological Process

Cholesterol metabolic process Source: UniProtKB-UniPathway
Generation of precursor metabolites and energy Source: ProtInc
Steroid biosynthetic process Source: ProtInc
Ubiquinone biosynthetic process Source: GO_Central

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Auditory neuropathy and optic atrophy (ANOA):
An autosomal recessive disease characterized by hearing loss, visual impairment and optic atrophy, with onset in the first or second decades of life. Optic atrophy is caused by degeneration of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts.

Anti-FDXR antibodies

Mouse Anti-FDXR Recombinant Antibody (CBXF-0487) (CBMAB-F2297-CQ)

Datasheet

SDS

Target: FDXR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0487

Application*: E, WB

Mouse Anti-FDXR Recombinant Antibody (CBXF-3763) (CBMAB-F1931-CQ)

Datasheet

SDS

Target: FDXR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-3763

Application*: E, P, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)