FRZB
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
Full Name
frizzled-related protein
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Biological Process
Canonical Wnt signaling pathway Source: GO_Central
Cochlea morphogenesis Source: Ensembl
Convergent extension involved in organogenesis Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of cartilage development Source: Ensembl
Negative regulation of cell development Source: Ensembl
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of hepatocyte differentiation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Neural crest cell differentiation Source: Ensembl
Positive regulation of apoptotic process Source: MGI
Positive regulation of fat cell differentiation Source: MGI
Skeletal system development Source: ProtInc
Somite development Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Convergent extension involved in organogenesis Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of cartilage development Source: Ensembl
Negative regulation of cell development Source: Ensembl
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of hepatocyte differentiation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Neural crest cell differentiation Source: Ensembl
Positive regulation of apoptotic process Source: MGI
Positive regulation of fat cell differentiation Source: MGI
Skeletal system development Source: ProtInc
Somite development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Osteoarthritis 1 (OS1):
A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement.
A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement.
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Anti-FRZB antibodies
Products List
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CompareTarget: FRZB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4B8
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H8
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E5
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2574
Application*: WB
Target: FRZB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-1677
Application*: WB, EC
Target: FRZB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-1676
Application*: WB, IP, IF, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0020
Application*: E, WB
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5071
Application*: E, WB
Target: FRZB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5984
Application*: WB
Target: FRZB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3200
Application*: E, WB
Target: FRZB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1801
Application*: WB, IP, IF, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2574
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-1677
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-0020
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5071
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5984
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3200
Application*: WB, E
Target: FRZB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-1801
Application*: WB, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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