Mouse Anti-FRZB Recombinant Antibody (CBXS-0020) (CBMAB-S3025-CQ)

Name: Mouse Anti-FRZB Recombinant Antibody (CBXS-0020)
SKU: CBMAB-S3025-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-0020

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 5% trehalose, 40% glycerol

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

frizzled-related protein

Introduction

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.

Entrez Gene ID

2487

UniProt ID

Q92765

Alternative Names

Frizzled Related Protein; Secreted Frizzled-Related Protein 3; Frizzled-Related Protein 1; Frezzled; FRZB-1; SFRP-3; FRITZ; FRZB1; SFRP3; FRE; Frizzled Homolog-Related;

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

Biological Process

Canonical Wnt signaling pathway Source: GO_Central
Cochlea morphogenesis Source: Ensembl
Convergent extension involved in organogenesis Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of cartilage development Source: Ensembl
Negative regulation of cell development Source: Ensembl
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of hepatocyte differentiation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Neural crest cell differentiation Source: Ensembl
Positive regulation of apoptotic process Source: MGI
Positive regulation of fat cell differentiation Source: MGI
Skeletal system development Source: ProtInc
Somite development Source: Ensembl

Cellular Location

Secreted

Involvement in disease

Osteoarthritis 1 (OS1):
A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement.

Tuerlings, M., van Hoolwerff, M., van Bokkum, J. M., Suchiman, H. E. D., Lakenberg, N., Broekhuis, D., ... & Meulenbelt, I. (2022). Long non-coding RNA expression profiling of subchondral bone reveals AC005165. 1 modifying FRZB expression during osteoarthritis. Rheumatology, 61(7), 3023-3032.

Xu, R., Zhang, F., Lu, J., Wang, K., Pan, P., Sun, Y., & Zhang, Y. (2021). Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip. Aging (Albany NY), 13(8), 11281.

Huang, X., Zhong, L., van Helvoort, E., Lafeber, F., Mastbergen, S., Hendriks, J., ... & Karperien, M. (2021). The expressions of Dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity. Cartilage, 12(4), 496-504.

Casas-Fraile, L., Cornelis, F. M., Costamagna, D., Rico, A., Duelen, R., Sampaolesi, M. M., ... & Sáenz, A. (2020). Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels. Orphanet Journal of Rare Diseases, 15(1), 1-18.

Kwan, T., Kazamel, M., Thoenes, K., Si, Y., Jiang, N., & King, P. H. (2020). Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis. Scientific reports, 10(1), 16679.

Claudel, M., Jouzeau, J. Y., & Cailotto, F. (2019). Secreted Frizzled‐related proteins (sFRPs) in osteo‐articular diseases: much more than simple antagonists of Wnt signaling?. The FEBS Journal, 286(24), 4832-4851.

Casas-Fraile, L., Cornelis, F. M., Costamagna, D., Rico, A., Sampaolesi, M., de Munain, A. L., ... & Lories, R. J. (2018). Effect of frizzled related protein (FRZB) on muscles: an inverse relationship between FRZB and calpain-3 with potential impact on muscle dystrophy and osteoarthritis. Osteoarthritis and Cartilage, 26, S401.

Huang, X., Post, J. N., Zhong, L., Leijten, J., Larsson, S., Karperien, M., & Struglics, A. (2018). Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis. Osteoarthritis and cartilage, 26(6), 834-843.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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