GJC3
This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.[provided by RefSeq, Feb 2010]
Full Name
Gap Junction Protein Gamma 3
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Biological Process
AV node cell to bundle of His cell communication by electrical coupling Source: GOC
Cell-cell signaling Source: GO_Central
Cell-cell signaling Source: GO_Central
Cellular Location
Cell membrane; Gap junction
Topology
Cytoplasmic: 1-22
Helical: 23-43
Extracellular: 44-75
Helical: 76-96
Cytoplasmic: 97-132
Helical: 133-153
Extracellular: 154-194
Helical: 195-215
Cytoplasmic: 216-279
Helical: 23-43
Extracellular: 44-75
Helical: 76-96
Cytoplasmic: 97-132
Helical: 133-153
Extracellular: 154-194
Helical: 195-215
Cytoplasmic: 216-279
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Anti-GJC3 antibodies
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Target: GJC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1322
Application*: WB: 1:500~1:1000 ELISA: 1:40000
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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