GPR37L1

GPR37L1 has biased expression in brain (RPKM 18.1) and colon (RPKM 0.5).

Full Name

G protein-coupled receptor 37 like 1

Function

G-protein coupled receptor (PubMed:27072655).

Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594).

However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853).

It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655).

Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity).

Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity).

Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of smoothened signaling pathway Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: UniProtKB
Positive regulation of cerebellar granule cell precursor proliferation Source: Ensembl
Positive regulation of MAPK cascade Source: ParkinsonsUK-UCL

Cellular Location

Cell membrane; Cilium membrane. Associates with the basal membrane of Bergmann glia cell primary cilia.

Topology

Extracellular: 26-134
Helical: 135-155
Cytoplasmic: 156-167
Helical: 168-188
Extracellular: 189-205
Helical: 206-226
Cytoplasmic: 227-251
Helical: 252-272
Extracellular: 273-310
Helical: 311-331
Cytoplasmic: 332-361
Helical: 362-382
Extracellular: 383-398
Helical: 399-419
Cytoplasmic: 420-481

PTM

O-glycosylated.
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.
Ubiquitinated.