Rabbit Anti-GPR37L1 Recombinant Antibody (EG1149) (CBMAB-EN1374-LY)

Name: Rabbit Anti-GPR37L1 Recombinant Antibody (EG1149)
SKU: CBMAB-EN1374-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1149

Application

WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:1000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human ETBR2.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G protein-coupled receptor 37 like 1

Entrez Gene ID

9283

UniProt ID

O60883

Function

G-protein coupled receptor (PubMed:27072655).

Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594).

However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853).

It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655).

Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity).

Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity).

Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of smoothened signaling pathway Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: UniProtKB
Positive regulation of cerebellar granule cell precursor proliferation Source: Ensembl
Positive regulation of MAPK cascade Source: ParkinsonsUK-UCL

Cellular Location

Cell membrane; Cilium membrane. Associates with the basal membrane of Bergmann glia cell primary cilia.

Topology

Extracellular: 26-134
Helical: 135-155
Cytoplasmic: 156-167
Helical: 168-188
Extracellular: 189-205
Helical: 206-226
Cytoplasmic: 227-251
Helical: 252-272
Extracellular: 273-310
Helical: 311-331
Cytoplasmic: 332-361
Helical: 362-382
Extracellular: 383-398
Helical: 399-419
Cytoplasmic: 420-481

PTM

O-glycosylated.
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.
Ubiquitinated.

Sohel, M. S. H., Homma, T., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein–coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear. Cell and Tissue Research, 1-17.

Kitamura, K., Homma, T., Sohel, M. S. H., Fuyuki, A., Miyawaki, S., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. Tissue and Cell, 82, 102093.

Mouat, M. A., Wilkins, B. P., Ding, E., Govindaraju, H., Coleman, J. L., Graham, R. M., ... & Smith, N. J. (2022). Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. Cells, 11(11), 1814.

Alonso-Gardón, M., Elorza-Vidal, X., Castellanos, A., La Sala, G., Armand-Ugon, M., Gilbert, A., ... & Estévez, R. (2021). Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins. Human Molecular Genetics, 30(17), 1649-1665.

Sarkar, S., Homma, T., Onouchi, S., Shimizu, Y., Shiina, T., Nabeka, H., ... & Saito, S. (2021). Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. Journal of Veterinary Medical Science, 83(1), 1-8.

An, J., Zhang, Y., Fudge, A. D., Lu, H., Richardson, W. D., & Li, H. (2021). G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation. Developmental Neurobiology, 81(8), 975-984.

Mouat, M. A., Jackson, K. L., Coleman, J. L., Paterson, M. R., Graham, R. M., Head, G. A., & Smith, N. J. (2021). Deletion of orphan G protein-coupled receptor GPR37L1 in mice alters cardiovascular homeostasis in a sex-specific manner. Frontiers in pharmacology, 11, 600266.

Zheng, X., Asico, L. D., Ma, X., & Konkalmatt, P. R. (2019). G protein-coupled receptor 37L1 regulates renal sodium transport and blood pressure. American Journal of Physiology-Renal Physiology, 316(3), F506-F516.

Liu, B., Mosienko, V., Vaccari Cardoso, B., Prokudina, D., Huentelman, M., Teschemacher, A. G., & Kasparov, S. (2018). Glio‐and neuro‐protection by prosaposin is mediated by orphan G‐protein coupled receptors GPR37L1 and GPR37. Glia, 66(11), 2414-2426.

Jolly, S., Bazargani, N., Quiroga, A. C., Pringle, N. P., Attwell, D., Richardson, W. D., & Li, H. (2018). G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. Glia, 66(1), 47-61.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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