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Rabbit Anti-GPR37L1 Recombinant Antibody (D8F5Q) (CBMAB-CP0863-LY)

The product is antibody recognizes GPR37L1. The antibody D8F5Q immunoassay techniques such as: WB.
See all GPR37L1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D8F5Q
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala53 of human GPR37L1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 37 like 1
Entrez Gene ID
9283
UniProt ID
O60883
Alternative Names
ETBRLP2; ETBR-LP-2; ET(B)R-LP-2
Function
G-protein coupled receptor (PubMed:27072655).

Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594).

However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853).

It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655).

Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity).

Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity).

Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of astrocyte differentiation Source: Ensembl
Negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
Negative regulation of neuron differentiation Source: Ensembl
Negative regulation of smoothened signaling pathway Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: UniProtKB
Positive regulation of cerebellar granule cell precursor proliferation Source: Ensembl
Positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
Cellular Location
Cell membrane; Cilium membrane. Associates with the basal membrane of Bergmann glia cell primary cilia.
Topology
Extracellular: 26-134
Helical: 135-155
Cytoplasmic: 156-167
Helical: 168-188
Extracellular: 189-205
Helical: 206-226
Cytoplasmic: 227-251
Helical: 252-272
Extracellular: 273-310
Helical: 311-331
Cytoplasmic: 332-361
Helical: 362-382
Extracellular: 383-398
Helical: 399-419
Cytoplasmic: 420-481
PTM
O-glycosylated.
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.
Ubiquitinated.

Sohel, M. S. H., Homma, T., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein–coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear. Cell and Tissue Research, 1-17.

Kitamura, K., Homma, T., Sohel, M. S. H., Fuyuki, A., Miyawaki, S., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. Tissue and Cell, 82, 102093.

Mouat, M. A., Wilkins, B. P., Ding, E., Govindaraju, H., Coleman, J. L., Graham, R. M., ... & Smith, N. J. (2022). Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. Cells, 11(11), 1814.

Alonso-Gardón, M., Elorza-Vidal, X., Castellanos, A., La Sala, G., Armand-Ugon, M., Gilbert, A., ... & Estévez, R. (2021). Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins. Human Molecular Genetics, 30(17), 1649-1665.

Sarkar, S., Homma, T., Onouchi, S., Shimizu, Y., Shiina, T., Nabeka, H., ... & Saito, S. (2021). Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. Journal of Veterinary Medical Science, 83(1), 1-8.

An, J., Zhang, Y., Fudge, A. D., Lu, H., Richardson, W. D., & Li, H. (2021). G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation. Developmental Neurobiology, 81(8), 975-984.

Mouat, M. A., Jackson, K. L., Coleman, J. L., Paterson, M. R., Graham, R. M., Head, G. A., & Smith, N. J. (2021). Deletion of orphan G protein-coupled receptor GPR37L1 in mice alters cardiovascular homeostasis in a sex-specific manner. Frontiers in pharmacology, 11, 600266.

Zheng, X., Asico, L. D., Ma, X., & Konkalmatt, P. R. (2019). G protein-coupled receptor 37L1 regulates renal sodium transport and blood pressure. American Journal of Physiology-Renal Physiology, 316(3), F506-F516.

Liu, B., Mosienko, V., Vaccari Cardoso, B., Prokudina, D., Huentelman, M., Teschemacher, A. G., & Kasparov, S. (2018). Glio‐and neuro‐protection by prosaposin is mediated by orphan G‐protein coupled receptors GPR37L1 and GPR37. Glia, 66(11), 2414-2426.

Jolly, S., Bazargani, N., Quiroga, A. C., Pringle, N. P., Attwell, D., Richardson, W. D., & Li, H. (2018). G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. Glia, 66(1), 47-61.

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For research use only. Not intended for any clinical use.

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