GSTO1
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Full Name
Glutathione S-Transferase Omega 1
Function
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Biological Process
Cellular response to arsenic-containing substance Source: UniProtKB
Glutathione metabolic process Source: GO_Central
L-ascorbic acid metabolic process Source: UniProtKB
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Xenobiotic catabolic process Source: UniProtKB
Glutathione metabolic process Source: GO_Central
L-ascorbic acid metabolic process Source: UniProtKB
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Xenobiotic catabolic process Source: UniProtKB
Cellular Location
Cytosol
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Anti-GSTO1 antibodies
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CompareTarget: GSTO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-2048
Application*: WB, E
Target: GSTO1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-2044
Application*: WB, E, IH
Target: GSTO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D9
Application*: WB, E, IP
Target: GSTO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 1B6
Application*: WB, IF, IH
Target: GSTO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 6
Application*: WB, E, IP
Target: GSTO1
Sensitivity: 0.0092 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: GSTO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-059
Application*: WB, IF
Target: GSTO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYC-P080
Application*: WB, E
Target: GSTO1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBLG1-2051
Application*: WB, E, IH
Target: GSTO1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBLG1-2040
Application*: WB, E
Target: GSTO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2C7
Application*: E, WB, IH, IF
Target: GSTO1
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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