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Mouse Anti-GSTO1 Recombinant Antibody (CBLG1-2051) (CBMAB-G5540-LY)

This product is antibody recognizes GSTO1. The antibody CBLG1-2051 immunoassay techniques such as: ELISA (EIA), WB.
See all GSTO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2051
Antibody Isotype
IgG2a
Application
ELISA (EIA), WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutathione S-Transferase Omega 1
Introduction
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Entrez Gene ID
9446
UniProt ID
P78417
Alternative Names
Glutathione S-Transferase Omega 1; Glutathione-Dependent Dehydroascorbate Reductase; Glutathione S-Transferase Omega 1-1; S-(Phenacyl)Glutathione Reductase; Monomethylarsonic Acid Reductase; MMA(V) Reductase; EC 2.5.1.18; GSTO 1-1; GSTTLp28; SPG-R;
Function
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Biological Process
Cellular response to arsenic-containing substance Source: UniProtKB
Glutathione metabolic process Source: GO_Central
L-ascorbic acid metabolic process Source: UniProtKB
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Xenobiotic catabolic process Source: UniProtKB
Cellular Location
Cytosol

Djukic, T., Stevanovic, G., Coric, V., Bukumiric, Z., Pljesa-Ercegovac, M., Matic, M., ... & Simic, T. (2022). GSTO1, GSTO2 and ACE2 polymorphisms modify susceptibility to developing COVID-19. Journal of Personalized Medicine, 12(3), 458.

Sobot, V., Stamenkovic, M., Simic, T., Jerotic, D., Djokic, M., Jaksic, V., ... & Djukic, T. (2022). Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. Experimental Eye Research, 214, 108863.

Paul, S., Bhardwaj, M., & Kang, S. C. (2022). GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20. International Journal of Oncology, 61(5), 1-12.

Oakley, A. J. (2022). Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1. Biochemical and Biophysical Research Communications, 590, 7-13.

Sokulsky, L. A., Goggins, B., Sherwin, S., Eyers, F., Kaiko, G. E., Board, P. G., ... & Foster, P. S. (2020). GSTO1‐1 is an upstream suppressor of M2 macrophage skewing and HIF‐1α‐induced eosinophilic airway inflammation. Clinical & Experimental Allergy, 50(5), 609-624.

Saisawang, C., Wongsantichon, J., Robinson, R. C., & Ketterman, A. J. (2019). Glutathione transferase Omega 1‐1 (GSTO1‐1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH‐SY5Y. Proteins: Structure, Function, and Bioinformatics, 87(7), 588-595.

Wang, J., Gao, Y., Cheng, X., Yang, J., Zhao, Y., Xu, H., ... & Wang, J. (2019). GSTO1 acts as a mediator in sodium fluoride-induced alterations of learning and memory related factors expressions in the hippocampus cell line. Chemosphere, 226, 201-209.

Radic, T., Coric, V., Bukumiric, Z., Pljesa-Ercegovac, M., Djukic, T., Avramovic, N., ... & Savic-Radojevic, A. (2019). GSTO1* CC Genotype (rs4925) predicts shorter survival in clear cell renal cell carcinoma male patients. Cancers, 11(12), 2038.

Li, L., Zhao, Y., Cao, R., Li, L., Cai, G., Li, J., ... & Zhang, Z. (2019). Activity-based protein profiling reveals GSTO1 as the covalent target of piperlongumine and a promising target for combination therapy for cancer. Chemical Communications, 55(30), 4407-4410.

Fernando, N., Wooff, Y., Aggio-Bruce, R., Chu-Tan, J. A., Jiao, H., Dietrich, C., ... & Natoli, R. (2018). Photoreceptor survival is regulated by GSTO1-1 in the degenerating retina. Investigative ophthalmology & visual science, 59(11), 4362-4374.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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