GUCY1A1
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene.
Full Name
Guanylate Cyclase 1 Soluble Subunit Alpha 1
Biological Process
Blood circulation Source: ProtInc
cGMP biosynthetic process Source: UniProtKB
Nitric oxide mediated signal transduction Source: ProtInc
Positive regulation of nitric oxide mediated signal transduction Source: Ensembl
Regulation of blood pressure Source: Ensembl
Relaxation of vascular associated smooth muscle Source: Ensembl
Retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Source: Ensembl
cGMP biosynthetic process Source: UniProtKB
Nitric oxide mediated signal transduction Source: ProtInc
Positive regulation of nitric oxide mediated signal transduction Source: Ensembl
Regulation of blood pressure Source: Ensembl
Relaxation of vascular associated smooth muscle Source: Ensembl
Retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Moyamoya disease 6 with or without achalasia (MYMY6):
A form of Moyamoya disease, a progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. MYMY6 is characterized by severe cerebral angiopathy and onset of severe achalasia in infancy or early childhood.
A form of Moyamoya disease, a progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. MYMY6 is characterized by severe cerebral angiopathy and onset of severe achalasia in infancy or early childhood.
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Anti-GUCY1A1 antibodies
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CompareTarget: GUCY1A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-3492
Application*: WB, E
Target: GUCY1A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3045
Application*: WB
Target: GUCY1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4455
Application*: WB, IH, IC, F
Target: GUCY1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4305
Application*: WB, IH, IC, F
Target: GUCY1A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H1
Application*: E, F, IF, IH, WB
Target: GUCY1A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 6B2
Application*: WB, E, IP, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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