Mouse Anti-GUCY1A1 Recombinant Antibody (3G6B2) (CBMAB-G0937-LY)

Name: Mouse Anti-GUCY1A1 Recombinant Antibody (3G6B2)
SKU: CBMAB-G0937-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3G6B2

Application

ELISA, FC

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.03% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Guanylate Cyclase 1 Soluble Subunit Alpha 1

Introduction

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Entrez Gene ID

2982

UniProt ID

Q02108

Alternative Names

Guanylate Cyclase 1 Soluble Subunit Alpha 1; GUCY1A3; Guanylate Cyclase 1 Soluble Subunit Alpha; Soluble Guanylate Cyclase Large Subunit; Guanylate Cyclase 1; Soluble; Alpha 3; GCS-Alpha-3; EC 4.6.1.2; GUC1A3;

Biological Process

Blood circulation Source: ProtInc
cGMP biosynthetic process Source: UniProtKB
Nitric oxide mediated signal transduction Source: ProtInc
Positive regulation of nitric oxide mediated signal transduction Source: Ensembl
Regulation of blood pressure Source: Ensembl
Relaxation of vascular associated smooth muscle Source: Ensembl
Retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Source: Ensembl

Cellular Location

Cytoplasm

Involvement in disease

Moyamoya disease 6 with or without achalasia (MYMY6):
A form of Moyamoya disease, a progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. MYMY6 is characterized by severe cerebral angiopathy and onset of severe achalasia in infancy or early childhood.

Malinowski, D., Zawadzka, M., Safranow, K., Droździk, M., & Pawlik, A. (2022). SELL and GUCY1A1 Gene Polymorphisms in Patients with Unstable Angina. Biomedicines, 10(10), 2494.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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