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Mouse Anti-GUCY1A1 Recombinant Antibody (CBFYH-3492) (CBMAB-H4042-FY)

This product is mouse antibody that recognizes GUCY1A1. The antibody CBFYH-3492 can be used for immunoassay techniques such as: ELISA, WB.
See all GUCY1A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3492
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human soluble guanylate cyclase a1b1 heterodimer
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Guanylate Cyclase 1 Soluble Subunit Alpha 1
Introduction
Patients with homozygous mutations in GUCY1A3 (recently re-namedGUCY1A1), which encodes the α1 subunit of sGC, develop autosomal-recessivemoyamoya and early-onset achalasia.
Entrez Gene ID
2982
UniProt ID
Q02108
Alternative Names
GUCA3; MYMY6; GC-SA3; GUC1A3; GUCSA3; GUCY1A3
Biological Process
Blood circulation Source: ProtInc
cGMP biosynthetic process Source: UniProtKB
Nitric oxide mediated signal transduction Source: ProtInc
Positive regulation of nitric oxide mediated signal transduction Source: Ensembl
Regulation of blood pressure Source: Ensembl
Relaxation of vascular associated smooth muscle Source: Ensembl
Retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Source: Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Moyamoya disease 6 with or without achalasia (MYMY6):
A form of Moyamoya disease, a progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. MYMY6 is characterized by severe cerebral angiopathy and onset of severe achalasia in infancy or early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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