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HAND1

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
Full Name
heart and neural crest derivatives expressed 1
Function
Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity).

Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).

Acts as a transcriptional repressor of SOX15 (By similarity).

In the adult, could be required for ongoing expression of cardiac-specific genes (PubMed:9931445).
Biological Process
Angiogenesis Source: BHF-UCL
Blastocyst development Source: BHF-UCL
Cardiac left ventricle formation Source: BHF-UCL
Cardiac right ventricle formation Source: BHF-UCL
Cardiac septum morphogenesis Source: BHF-UCL
Cartilage morphogenesis Source: Ensembl
Developmental process Source: GO_Central
Embryonic heart tube development Source: BHF-UCL
Embryonic heart tube formation Source: Ensembl
Heart development Source: BHF-UCL
Heart looping Source: BHF-UCL
Mesenchyme development Source: Ensembl
Mesoderm formation Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Trophectodermal cell differentiation Source: BHF-UCL
Trophoblast giant cell differentiation Source: UniProtKB
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Cellular Location
Nucleoplasm; Nucleolus. Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity).
PTM
Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity.

Anti-HAND1 antibodies

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Target: HAND1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A9
Application*: IP, M
Target: HAND1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D5
Application*: IP, WB, M
Target: HAND1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0674
Application*: WB, F, IF
Target: HAND1
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYE-1457
Application*: WB, IP, IF, E
Target: HAND1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1474
Application*: IF: 1:100~1:500 ELISA: 1:10000
Target: HAND1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8E7A11,8C2F4
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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