HAUS6

The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Full Name

HAUS Augmin Like Complex Subunit 6

Function

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.

Biological Process

Cell division Source: UniProtKB-KW
Centrosome cycle Source: UniProtKB
Microtubule cytoskeleton organization Source: GO_Central
Spindle assembly Source: UniProtKB

Cellular Location

Cytoskeleton; Spindle; Centrosome. Localizes to interphase centrosomes and to mitotic spindle microtubules.

PTM

Phosphorylated during mitosis.