HSD17B7

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM

Full Name

hydroxysteroid (17-beta) dehydrogenase 7

Function

Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030).

Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193).

Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030).

Isoform 3:
Does not have enzymatic activities toward E1 and DHT.

Biological Process

Androgen metabolic process Source: UniProtKB
Cholesterol biosynthetic process Source: UniProtKB
Estrogen biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Topology

Extracellular: 1-229
Helical: 230-250
Cytoplasmic: 251-341

PTM

Phosphorylated.