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Mouse Anti-HSD17B7 (AA 255-341) Recombinant Antibody (CBFYH-2016) (CBMAB-H3027-FY)

This product is mouse antibody that recognizes HSD17B7. The antibody CBFYH-2016 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all HSD17B7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2016
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: NAFTLTPYNG TEALVWLFHQ KPESLNPLIK YLSATTGFGR NYIMTQKMDL DEDTAEKFYQ KLLELEKHIR VTIQKTDNQA RLSGSCL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 255-341

Target

Full Name
hydroxysteroid (17-beta) dehydrogenase 7
Introduction
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).
Entrez Gene ID
51478
UniProt ID
P56937
Alternative Names
Hydroxysteroid 17-Beta Dehydrogenase 7; Short Chain Dehydrogenase/Reductase Family 37C Member 1; 17-Beta-Hydroxysteroid Dehydrogenase 7; Estradiol 17-Beta-Dehydrogenase 7; 17-Beta-HSD 7; SDR37C1; Short Chain Dehydrogenase/Reductase Family 37C, Member 1; 17 Beta-Hydroxysteroid Dehydrogenase Type VII
Function
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030).

Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193).

Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030).

Isoform 3:
Does not have enzymatic activities toward E1 and DHT.
Biological Process
Androgen metabolic process Source: UniProtKB
Cholesterol biosynthetic process Source: UniProtKB
Estrogen biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Topology
Extracellular: 1-229
Helical: 230-250
Cytoplasmic: 251-341
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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