Mouse Anti-HSD17B7 (AA 255-341) Recombinant Antibody (CBFYH-2016) (CBMAB-H3027-FY)

Name: Mouse Anti-HSD17B7 (AA 255-341) Recombinant Antibody (CBFYH-2016)
SKU: CBMAB-H3027-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2016

Application

ELISA, IF, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: NAFTLTPYNG TEALVWLFHQ KPESLNPLIK YLSATTGFGR NYIMTQKMDL DEDTAEKFYQ KLLELEKHIR VTIQKTDNQA RLSGSCL

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 255-341

More Infomation

Target

Full Name

hydroxysteroid (17-beta) dehydrogenase 7

Introduction

HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).

Entrez Gene ID

51478

UniProt ID

P56937

Alternative Names

Hydroxysteroid 17-Beta Dehydrogenase 7; Short Chain Dehydrogenase/Reductase Family 37C Member 1; 17-Beta-Hydroxysteroid Dehydrogenase 7; Estradiol 17-Beta-Dehydrogenase 7; 17-Beta-HSD 7; SDR37C1; Short Chain Dehydrogenase/Reductase Family 37C, Member 1; 17 Beta-Hydroxysteroid Dehydrogenase Type VII

Function

Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030).

Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289).

Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193).

Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030).

Isoform 3:
Does not have enzymatic activities toward E1 and DHT.

Biological Process

Androgen metabolic process Source: UniProtKB
Cholesterol biosynthetic process Source: UniProtKB
Estrogen biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Topology

Extracellular: 1-229
Helical: 230-250
Cytoplasmic: 251-341

PTM

Phosphorylated.

Wang, D., Li, Y., Zhai, Q. Q., Zhu, Y. F., Liu, B. Y., & Xu, Y. (2022). Quercetin ameliorates testosterone secretion disorder by inhibiting endoplasmic reticulum stress through the miR-1306-5p/HSD17B7 axis in diabetic rats. Bosnian Journal of Basic Medical Sciences, 22(2), 191.

Pleshinger, M. J., Friedrich, R. M., Hubler, Z., Rivera-León, A. M., Gao, F., Yan, D., ... & Adams, D. J. (2022). Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation. RSC Chemical Biology, 3(1), 56-68.

Xu, X., Tassone, B., Ostano, P., Katarkar, A., Proust, T., Joseph, J. M., ... & Dotto, G. P. (2021). HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations. EMBO Molecular Medicine, 13(7), e14133.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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