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HTATIP2

NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import.

Full Name

HIV-1 Tat interactive protein 2, 30kDa

Function

Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Biological Process

Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Import into nucleus Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of programmed cell death Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Protein autophosphorylation Source: MGI
Regulation of angiogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc

Cellular Location

Cytoplasm; Nucleus envelope

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Anti-HTATIP2 antibodies

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Mouse Anti-HTATIP2 Recombinant Antibody (3E11) (CBMAB-A4148-LY)

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Target: HTATIP2

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: 3E11

Application*: E, E

Rabbit Anti-HTATIP2 Recombinant Antibody (CBYJT-1385) (CBMAB-T0407-YJ)

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Target: HTATIP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-1385

Application*: WB, IP, P, F, IC, IF

Mouse Anti-HTATIP2 Recombinant Antibody (CBYJT-1384) (CBMAB-T0406-YJ)

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Target: HTATIP2

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: CBYJT-1384

Application*: E

Mouse Anti-HTATIP2 Recombinant Antibody (CBYJT-1383) (CBMAB-T0405-YJ)

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Target: HTATIP2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1383

Application*: WB, IP, IF, E

Mouse Anti-HTATIP2 Recombinant Antibody (CBYJT-1382) (CBMAB-T0404-YJ)

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Target: HTATIP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-1382

Application*: WB, F, E, IC, IF

Mouse Anti-HTATIP2 (AA 1-242) Recombinant Antibody (CBFYH-2486) (CBMAB-H3501-FY)

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Target: HTATIP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-2486

Application*: E

Mouse Anti-HTATIP2 Recombinant Antibody (422D2a) (CBMAB-H3500-FY)

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Target: HTATIP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 422D2a

Application*: DB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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