IAPP

This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]

Full Name

Islet Amyloid Polypeptide

Function

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: ARUK-UCL
Amylin receptor signaling pathway Source: ARUK-UCL
Amyloid fibril formation Source: UniProtKB
Apoptotic process Source: ProtInc
Cell-cell signaling Source: ProtInc
Eating behavior Source: Ensembl
Negative regulation of amyloid fibril formation Source: ARUK-UCL
Negative regulation of bone resorption Source: Ensembl
Negative regulation of cell differentiation Source: Ensembl
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of mitochondrion organization Source: ARUK-UCL
Negative regulation of protein-containing complex assembly Source: ARUK-UCL
Positive regulation of apoptotic process Source: ARUK-UCL
Positive regulation of calcium ion import across plasma membrane Source: ARUK-UCL
Positive regulation of cell death Source: ARUK-UCL
Positive regulation of cytosolic calcium ion concentration Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of MAPK cascade Source: ARUK-UCL
Positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
Positive regulation of protein kinase A signaling Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Protein destabilization Source: UniProtKB
Protein homooligomerization Source: UniProtKB
Sensory perception of pain Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

Amyloid fibrils are degraded by IDE.