IGF2R

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Full Name
Insulin Like Growth Factor 2 Receptor
Function
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523).

Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523).

The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523).

This receptor also binds IGF2 (PubMed:18046459).

Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005).
Biological Process
Animal organ regeneration Source: Ensembl
G protein-coupled receptor signaling pathway Source: Ensembl
Liver development Source: Ensembl
Lysosomal transport Source: InterPro
Positive regulation by host of viral process Source: ARUK-UCL
Positive regulation of apoptotic process Source: Ensembl
Post-embryonic development Source: Ensembl
Receptor-mediated endocytosis Source: ProtInc
Response to retinoic acid Source: Ensembl
Response to tetrachloromethane Source: Ensembl
Signal transduction Source: ProtInc
Spermatogenesis Source: Ensembl
Cellular Location
Endosome membrane; Golgi apparatus membrane. Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005).
Topology
Lumenal: 41-2304
Helical: 2305-2327
Cytoplasmic: 2328-2491
PTM
Palmitoylated (PubMed:18817523). Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus (PubMed:18817523).
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Anti-IGF2R antibodies

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Mouse Anti-IGF2R Recombinant Antibody (86f7) (CBMAB-0302-CN)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Mouse
Clone: 86f7
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (CBT2697) (V2LY-0625-LY1199)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2697
Application*: WB
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (CBT4667) (V2LY-0625-LY1198)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4667
Application*: F
Datasheet SDS

Rabbit Anti-IGF2R Recombinant Antibody (A433) (CBMAB-AP10815LY)

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Target: IGF2R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A433
Application*: FC, ICC, IF, IHC, WB
Datasheet SDS

Rabbit Anti-IGF2R Recombinant Antibody (A432) (CBMAB-AP10845LY)

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Target: IGF2R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A432
Application*: FC, ICC, IF, IHC, IP, WB
Datasheet SDS

Recombinant Rabbit Anti-IGF2R Antibody (CBAb135) (CBMAB-Ab135-LY)

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Target: IGF2R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb135
Application*: WB, IH, IF, IP
Datasheet SDS

Rabbit Anti-IGF2R Recombinant Antibody (D3V8C) (CBMAB-CP1114-LY)

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Target: IGF2R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D3V8C
Application*: WB, IP, IF (IC)
Datasheet SDS

Rabbit Anti-IGF2R Recombinant Antibody (D8Z3J) (CBMAB-CP1113-LY)

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Target: IGF2R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D8Z3J
Application*: WB, P
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (3H1996) (CBMAB-C3592-CN)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 3H1996
Application*: FC
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (CBYY-C2554) (CBMAB-C3995-YY)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2554
Application*: F, WB
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (CBYY-C2553) (CBMAB-C3994-YY)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBYY-C2553
Application*: F
Datasheet SDS

Rabbit Anti-IGF2R Recombinant Antibody (CBYY-I1667) (CBMAB-I2837-YY)

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Target: IGF2R
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYY-I1667
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (CBYY-I1209) (CBMAB-I2378-YY)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1209
Application*: E
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (MEM-238) (CBMAB-I0850-YY)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-238
Application*: WB, F, MC
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (2G11) (CBMAB-I0089-YY)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Dog
Clone: 2G11
Application*: WB, F, E, IH, IF, IP, P, MC
Datasheet SDS

Mouse Anti-IGF2R Recombinant Antibody (8J234) (CBMAB-C9261-LY)

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Target: IGF2R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J234
Application*: C, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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