IGFBP7

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
Full Name
insulin like growth factor binding protein 7
Function
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Biological Process
Cell adhesion Source: UniProtKB
Cellular response to hormone stimulus Source: Ensembl
Embryo implantation Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Regulation of cell growth Source: InterPro
Regulation of signal transduction Source: GO_Central
Regulation of steroid biosynthetic process Source: Ensembl
Response to cortisol Source: Ensembl
Response to heat Source: Ensembl
Response to retinoic acid Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS):
An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
PTM
N-glycosylated.
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Anti-IGFBP7 antibodies

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Mouse Anti-IGFBP7 Recombinant Antibody (CBXF-0939) (CBMAB-F1457-CQ)

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Target: IGFBP7
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-0939
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-IGFBP7 Recombinant Antibody (CBXF-1376) (CBMAB-F1308-CQ)

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Target: IGFBP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1376
Application*: E
Datasheet SDS

Rabbit Anti-IGFBP7 Recombinant Antibody (CBXF-2038) (CBMAB-F1168-CQ)

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Target: IGFBP7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2038
Application*: E
Datasheet SDS

Mouse Anti-IGFBP7 Recombinant Antibody (CBT3780) (V2LY-0625-LY43)

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Target: IGFBP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3780
Application*: WB
Datasheet SDS

Mouse Anti-IGFBP7 Recombinant Antibody (CBT3265) (V2LY-0625-LY42)

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Target: IGFBP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3265
Application*: IH
Datasheet SDS

Rabbit Anti-IGFBP7 Recombinant Antibody (EG1598) (CBMAB-EN1911-LY)

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Target: IGFBP7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1598
Application*: IHC: 1:50~1:100 ELISA: 1:40000
Datasheet SDS

Rat Anti-IGFBP7 Recombinant Antibody (CBYY-I0064) (CBMAB-I0156-YY)

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Target: IGFBP7
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0064
Application*: IH
Datasheet SDS

Rat Anti-IGFBP7 Recombinant Antibody (CBYY-I0063) (CBMAB-I0155-YY)

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Target: IGFBP7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0063
Application*: WB
Datasheet SDS

Mouse Anti-IGFBP7 Recombinant Antibody (1D9E7) (CBMAB-I0154-YY)

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Target: IGFBP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D9E7
Application*: E, WB, P
Datasheet SDS

Mouse Anti-IGFBP7 Recombinant Antibody (CBYY-I0062) (CBMAB-I0153-YY)

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Target: IGFBP7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0062
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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