Human Recombinant IGFBP7 protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY4675)

Name: Human Recombinant IGFBP7 protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY4675
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & AVI Tag

Protein Construction

This product is Human Recombinant IGFBP7 protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 30-282 and predicts a molecular mass of 29.37 kDa.

Molecule Mass

29.37 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 30-282

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

insulin like growth factor binding protein 7

Function

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Biological Process

Cell adhesion Source: UniProtKB
Cellular response to hormone stimulus Source: Ensembl
Embryo implantation Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Regulation of cell growth Source: InterPro
Regulation of signal transduction Source: GO_Central
Regulation of steroid biosynthetic process Source: Ensembl
Response to cortisol Source: Ensembl
Response to heat Source: Ensembl
Response to retinoic acid Source: Ensembl

Cellular Location

Secreted

Involvement in disease

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS):
An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

PTM

N-glycosylated.

Yi, X., Zheng, X., Xu, H., Li, J., Zhang, T., Ge, P., ... & Ai, J. (2022). IGFBP7 and the tumor immune landscape: a novel target for immunotherapy in bladder cancer. Frontiers in Immunology, 13, 898493.

Ko, T., Nomura, S., Yamada, S., Fujita, K., Fujita, T., Satoh, M., ... & Komuro, I. (2022). Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis. Nature communications, 13(1), 3275.

Zhao, Q., Zhao, R., Song, C., Wang, H., Rong, J., Wang, F., ... & Xie, Y. (2021). Increased IGFBP7 expression correlates with poor prognosis and immune infiltration in gastric cancer. Journal of Cancer, 12(5), 1343.

Jin, L., Shen, F., Weinfeld, M., & Sergi, C. (2020). Insulin growth factor binding protein 7 (IGFBP7)-related cancer and IGFBP3 and IGFBP7 crosstalk. Frontiers in Oncology, 10, 727.

Huang, X., Hong, C., Peng, Y., Yang, S., Huang, L., Liu, C., ... & Xu, Y. (2019). The diagnostic value of serum IGFBP7 in patients with esophageal squamous cell carcinoma. Journal of Cancer, 10(12), 2687.

Fejzo, M. S., Fasching, P. A., Schneider, M. O., Schwitulla, J., Beckmann, M. W., Schwenke, E., ... & Mullin, P. M. (2019). Analysis of GDF15 and IGFBP7 in hyperemesis gravidarum support causality. Geburtshilfe und Frauenheilkunde, 79(04), 382-388.

Zhang, L., Lian, R., Zhao, J., Feng, X., Ye, R., Pan, L., ... & Cai, J. (2019). IGFBP7 inhibits cell proliferation by suppressing AKT activity and cell cycle progression in thyroid carcinoma. Cell & bioscience, 9(1), 1-13.

Fejzo, M. S., Sazonova, O. V., Sathirapongsasuti, J. F., Hallgrímsdóttir, I. B., Vacic, V., MacGibbon, K. W., ... & Mullin, P. M. (2018). Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nature communications, 9(1), 1178.

Johnson, A. C., & Zager, R. A. (2018). Mechanisms underlying increased TIMP2 and IGFBP7 urinary excretion in experimental AKI. Journal of the American Society of Nephrology: JASN, 29(8), 2157.

Januzzi Jr, J. L., Packer, M., Claggett, B., Liu, J., Shah, A. M., Zile, M. R., ... & Solomon, S. D. (2018). IGFBP7 (insulin-like growth factor–binding protein-7) and neprilysin inhibition in patients with heart failure. Circulation: Heart Failure, 11(10), e005133.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IGFBP7 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY4673)

Human Recombinant IGFBP7 protein, hFc Tag (CAT#: V2LY-0526-LY4674)

Human Recombinant IGFBP7 protein, His Tag (CAT#: V2LY-0526-LY4676)

Human Recombinant IGFBP7 protein, His Tag-1 (CAT#: V2LY-0526-LY4677)

Human Recombinant IGFBP7 (K95R) protein, His Tag (CAT#: V2LY-0526-LY4678)

Mouse Recombinant IGFBP7 protein, hFc Tag (CAT#: V2LY-0526-LY8443)

Mouse Recombinant IGFBP7 protein, His Tag (CAT#: V2LY-0526-LY8444)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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