IL4RA

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

Full Name

Interleukin 4 Receptor

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.1 Publication
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Biological Process

Defense response to protozoanIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Immunoglobulin mediated immune responseIEA:Ensembl
Negative regulation of T-helper 1 cell differentiationIEA:Ensembl
OvulationIEA:Ensembl
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of immunoglobulin productionIEA:Ensembl
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of mast cell degranulationIEA:Ensembl
Positive regulation of myoblast fusionIEA:Ensembl
Positive regulation of T-helper 2 cell differentiationIEA:Ensembl
Production of molecular mediator involved in inflammatory responseIEA:InterPro
Regulation of cell population proliferationIEA:Ensembl
Response to estrogenIEA:Ensembl
Response to odorantIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Isoform 2: Secreted

Topology

Extracellular: 26-232
Helical: 233-256
Cytoplasmic: 257-825

PTM

On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.