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Human Anti-IL4RA Recombinant Antibody (CBXC-0761) (CBMAB-C1875-CQ)

This product is a recombinant human antibody that recognizes IL4RA. The antibody CBXC-0761 can be used for immunoassay techniques such as: FC.
See all IL4RA antibodies

Summary

Host Animal
Human
Specificity
Mouse
Clone
CBXC-0761
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 4 Receptor
Introduction
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
16190
UniProt ID
P16382
Alternative Names
Interleukin 4 Receptor
Function
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.1 Publication
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Biological Process
Defense response to protozoanIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Immunoglobulin mediated immune responseIEA:Ensembl
Negative regulation of T-helper 1 cell differentiationIEA:Ensembl
OvulationIEA:Ensembl
Positive regulation of chemokine productionIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of immunoglobulin productionIEA:Ensembl
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of mast cell degranulationIEA:Ensembl
Positive regulation of myoblast fusionIEA:Ensembl
Positive regulation of T-helper 2 cell differentiationIEA:Ensembl
Production of molecular mediator involved in inflammatory responseIEA:InterPro
Regulation of cell population proliferationIEA:Ensembl
Response to estrogenIEA:Ensembl
Response to odorantIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 26-232
Helical: 233-256
Cytoplasmic: 257-825
PTM
On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Pandit, D., Sharma, P., Yadav, H., Garg, K., Chopra, V., & Sharma, S. (2023). Association of IL4RA polymorphism in predicting susceptibility toward chronic obstructive pulmonary disease. Pharmacogenomics, 24(11), 615-627.

Jyotish, K., Joshi, J. L., Kansal, H., Chopra, V., Garg, K., Girdhar, N., ... & Sharma, S. (2023). Association of IL4RA and IL-8 polymorphism in predicting susceptibility towards tuberculosis. Monaldi Archives for Chest Disease.

Jurado-Escobar, R., Dona, I., Jimenez-Sanchez, I., Testera-Montes, A., Perez-Sanchez, N., Rondon, C., ... & Cornejo-Garcia, J. A. (2023). Association between House Dust Mite Sensitization and IL4/IL13 and IL4RA Genetic Variants in Nonsteroidal Anti-inflammatory Drug-induced Acute Urticaria/angioedema. Journal of Allergy and Clinical Immunology, 151(2), AB133.

Banzon, T. M., Kelly, M. S., Bartnikas, L. M., Sheehan, W. J., Cunningham, A., Harb, H., ... & Lai, P. S. (2022). Atopic dermatitis mediates the association between an IL4RA variant and food allergy in school-aged children. The Journal of Allergy and Clinical Immunology: In Practice, 10(8), 2117-2124.

Chetty, A., Darby, M. G., Vornewald, P. M., Martín-Alonso, M., Filz, A., Ritter, M., ... & Horsnell, W. G. (2021). Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection. Cell Host & Microbe, 29(4), 579-593.

Danielewicz, H., Dębińska, A., Drabik-Chamerska, A., Kalita, D., & Boznański, A. (2021). IL4RA gene expression in relation to I50V, Q551R and C-3223T polymorphisms. Advances in Clinical and Experimental Medicine, 30(1), 17-22.

Al‐Saffar, O. B., & Ad'hiah, A. H. (2020). Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients. Journal of Medical Virology, 92(12), 3448-3458.

Paddock, S. J., Alencar, V., Wodsedalek, D. J., & Omeara, C. (2020, July). IL4Ra is Required for Cardiomyocyte Cell Cycle Activity and Cardiac Regeneration. In Circulation Research (Vol. 127, No. Suppl_1, pp. A302-A302). Hagerstown, MD: Lippincott Williams & Wilkins.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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