INS2

This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism.

Full Name

insulin 2

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Biological Process

Canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:MGI
ER overload responseManual Assertion Based On ExperimentIMP:MGI
Glucose homeostasisManual Assertion Based On ExperimentIMP:MGI
Glucose metabolic processManual Assertion Based On ExperimentIMP:MGI
Glucose transmembrane transportManual Assertion Based On ExperimentTAS:MGI
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressManual Assertion Based On ExperimentIMP:MGI
Lipid catabolic processManual Assertion Based On ExperimentIDA:MGI
Myoblast fusionManual Assertion Based On ExperimentIGI:MGI
Myotube differentiationManual Assertion Based On ExperimentIGI:MGI
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIDA:MGI
Positive regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of gene expressionManual Assertion Based On ExperimentIDA:MGI
Regulation of phosphorylationManual Assertion Based On ExperimentIDA:MGI
Regulation of protein bindingManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Secreted