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JOSD1

JOSD1 is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Josephin domain DUBs. Gene Ontology (GO) annotations related to this gene include omega peptidase activity. An important paralog of this gene is JOSD2.

Full Name

Josephin domain containing 1

Function

Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.

Biological Process

Protein deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane; Cytoplasm. Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.

PTM

Monoubiquitinated (By similarity).
Ubiquitination activates deubiquitination activity in vitro.

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Anti-JOSD1 antibodies

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Mouse Anti-JOSD1 Recombinant Antibody (OTI3B11) (CBMAB-0419-WJ)

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Target: JOSD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: OTI3B11

Application*: WB, IH

Mouse Anti-JOSD1 Recombinant Antibody (3B11) (CBMAB-0167-WJ)

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Target: JOSD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3B11

Application*: WB, P

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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