Mouse Anti-JOSD1 Recombinant Antibody (OTI3B11) (CBMAB-0419-WJ)

Name: Mouse Anti-JOSD1 Recombinant Antibody (OTI3B11)
SKU: CBMAB-0419-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

OTI3B11

Application

WB, IHC

Immunogen

Full length recombinant protein of human JOSD1.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Josephin domain containing 1

Introduction

JOSD1 is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Josephin domain DUBs. Gene Ontology (GO) annotations related to this gene include omega peptidase activity. An important paralog of this gene is JOSD2.

Entrez Gene ID

9929

UniProt ID

Q15040

Alternative Names

dJ508I15.2

Function

Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.

Biological Process

Protein deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane; Cytoplasm. Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.

PTM

Monoubiquitinated (By similarity).
Ubiquitination activates deubiquitination activity in vitro.

Huang, S., Huang, J., Cui, M., Wu, X., Wang, M., Zhu, D., ... & Jia, R. (2022). Duck Tembusu virus inhibits type I interferon production through the JOSD1-SOCS1-IRF7 negative-feedback regulation pathway. Journal of Virology, 96(18), e00930-22.

Yang, J., Weisberg, E. L., Liu, X., Magin, R. S., Chan, W. C., Hu, B., ... & Buhrlage, S. J. (2022). Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2. Leukemia, 36(1), 210-220.

Ma, X., Qi, W., Yang, F., & Pan, H. (2022). Deubiquitinase JOSD1 promotes tumor progression via stabilizing Snail in lung adenocarcinoma. American Journal of Cancer Research, 12(5), 2323.

Jing, C., Liu, D., Lai, Q., Li, L., Zhou, M., Ye, B., ... & Wang, X. (2021). JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4. Cancer Cell International, 21(1), 1-12.

Wu, X., Luo, Q., Zhao, P., Chang, W., Wang, Y., Shu, T., ... & Liu, Z. (2020). JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1. Cell Death & Differentiation, 27(1), 55-70.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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