KATNB1

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.

katanin p80 (WD40-containing) subunit B 1

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Cell divisionIEA:UniProtKB-KW
Microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule severingIEA:UniProtKB-UniRule
Mitotic chromosome movement towards spindle poleIEA:UniProtKB-UniRule
Negative regulation of microtubule depolymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell deathIEA:Ensembl
Positive regulation of microtubule depolymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentIEA:Ensembl
Protein targeting1 PublicationNAS:UniProtKB

Cytoplasm; Cytoskeleton; Microtubule

Lissencephaly 6, with microcephaly (LIS6):
A form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS6 features include hypoplasia of the corpus callosum, severe microcephaly and developmental delay.