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Mouse Anti-KATNB1 Recombinant Antibody (3B6) (CBMAB-K0447-LY)

This product is antibody recognizes KATNB1. The antibody 3B6 immunoassay techniques such as: FC, IF, WB.
See all KATNB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B6
Antibody Isotype
IgG1
Application
FC, IF, WB

Basic Information

Immunogen
KATNB1 antibody was raised in mouse using a full length recombinant protein of human KATNB1 produced in HEK293T cells, as the immunogen
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg-1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
katanin p80 (WD40-containing) subunit B 1
Introduction
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
Entrez Gene ID
10300
UniProt ID
Q9BVA0
Alternative Names
Katanin Regulatory Subunit B1; Katanin P80 (WD Repeat Containing) Subunit B 1; Katanin P80 (WD40-Containing) Subunit B 1; Katanin P80 Subunit B1; P80 Katanin; Katanin P80 WD40 Repeat-Containing Subunit B1;
Function
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Biological Process
Cell divisionIEA:UniProtKB-KW
Microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule severingIEA:UniProtKB-UniRule
Mitotic chromosome movement towards spindle poleIEA:UniProtKB-UniRule
Negative regulation of microtubule depolymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell deathIEA:Ensembl
Positive regulation of microtubule depolymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentIEA:Ensembl
Protein targeting1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm; Cytoskeleton; Microtubule
Involvement in disease
Lissencephaly 6, with microcephaly (LIS6):
A form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS6 features include hypoplasia of the corpus callosum, severe microcephaly and developmental delay.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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