Mouse Anti-KATNB1 Recombinant Antibody (SPM274) (CBMAB-K0457-LY)

Name: Mouse Anti-KATNB1 Recombinant Antibody (SPM274)
SKU: CBMAB-K0457-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

SPM274

Application

WB, IHC-P, IP

Specificity

Human, Monkey

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

katanin p80 (WD40-containing) subunit B 1

Introduction

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	10300
Monkey	711862

UniProt ID

Human	Q9BVA0
Monkey	G7NPV4

Function

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Biological Process

Cell divisionIEA:UniProtKB-KW
Microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule severingIEA:UniProtKB-UniRule
Mitotic chromosome movement towards spindle poleIEA:UniProtKB-UniRule
Negative regulation of microtubule depolymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell deathIEA:Ensembl
Positive regulation of microtubule depolymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentIEA:Ensembl
Protein targeting1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm; Cytoskeleton; Microtubule

Involvement in disease

Lissencephaly 6, with microcephaly (LIS6):
A form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS6 features include hypoplasia of the corpus callosum, severe microcephaly and developmental delay.

Liu, T., Ma, J., Hou, D., Wang, W., & Cao, H. (2023). Haplotype-GGGT in long non-coding RNA MALAT1 inhibits brain metastatic lung cancer and lymph nodes of lung cancer via the MALAT1/miR-328/KATNB1. Aging (Albany NY), 15(6), 1918.

Meyer-Miner, A., Van Gennip, J. L., Henke, K., Harris, M. P., & Ciruna, B. (2022). Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model. Iscience, 25(9).

Dunleavy, J. E. M., O'Connor, A. E., Okuda, H., Merriner, D. J., & O'Bryan, M. K. (2021). KATNB1 is a master regulator of multiple katanin enzymes in male meiosis and haploid germ cell development. Development, 148(24), dev199922.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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