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KIF23

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Full Name

Kinesin Family Member 23

Function

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Biological Process

Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle elongationManual Assertion Based On ExperimentTAS:ProtInc
Mitotic spindle midzone assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring. Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

PTM

Ubiquitinated. Deubiquitinated by USP8/UBPY.

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Anti-KIF23 antibodies

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Rabbit Anti-KIF23 Recombinant Antibody (A759) (CBMAB-AP11115LY)

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Target: KIF23

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A759

Application*: ICC, IF, WB

Recombinant Rabbit Anti-KIF23 Antibody (CBAb144) (CBMAB-Ab144-LY)

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Target: KIF23

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb144

Application*: WB, IF

Rabbit Anti-KIF23 Recombinant Antibody (CBFYM-0300) (CBMAB-M0365-FY)

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Target: KIF23

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBFYM-0300

Application*: WB, IF

Rabbit Anti-KIF23 Recombinant Antibody (A1115) (CBMAB-AP11863LY)

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Target: KIF23

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A1115

Application*: ICC, IF, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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