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Recombinant Rabbit Anti-KIF23 Antibody (CBAb144) (CBMAB-Ab144-LY)

The product is antibody recognizes KIF23. The antibody CBAb144 immunoassay techniques such as: WB 1:500-1:2000; IF 1:50-1:200.
See all KIF23 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBAb144
Antibody Isotype
IgG
Application
WB 1:500-1:2000; IF 1:50-1:200

Basic Information

Immunogen
Recombinant protein of human KIF23
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinesin Family Member 23
Introduction
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants.
Entrez Gene ID
Human9493
Mouse71819
Rat315740
UniProt ID
HumanQ02241
MouseE9Q5G3
RatD4AAG4
Alternative Names
KIF23; CHO1; KNSL5; MKLP-1; MKLP1; kinesin family member 23
Function
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Biological Process
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle elongationManual Assertion Based On ExperimentTAS:ProtInc
Mitotic spindle midzone assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring. Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
PTM
Ubiquitinated. Deubiquitinated by USP8/UBPY.

Xu, Q., Li, X., Li, Y., Yu, J., & Yang, A. (2023). Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/β-catenin pathway. Functional & Integrative Genomics, 23(2), 154.

Li, Z., Yang, H. Y., Zhang, X. L., Zhang, X., Huang, Y. Z., Dai, X. Y., ... & Ding, Q. (2022). Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway. Journal of Experimental & Clinical Cancer Research, 41(1), 168.

He, X., Wang, J., Zhou, R., Yu, S., Jiang, J., & Zhou, Q. (2022). Kinesin family member 23 exerts a protumor function in breast cancer via stimulation of the Wnt/β-catenin pathway. Toxicology and Applied Pharmacology, 435, 115834.

Shen, E., Zhang, J., & Lu, Y. (2022). DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23). Bioengineered, 13(1), 1103-1114.

Yao, D. W., Qun, S. O. N. G., & He, X. Z. (2021). Kinesin family member 23 (KIF23) contributes to the progression of bladder cancer cells in vitro and in vivo. Neoplasma, 68(2).

Li, X., Huang, W., Huang, W., Wei, T., Zhu, W., Chen, G., & Zhang, J. (2020). Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. American Journal of Translational Research, 12(5), 1614.

Gao, C. T., Ren, J., Yu, J., Li, S. N., Guo, X. F., & Zhou, Y. Z. (2020). KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target. Annals of translational medicine, 8(21).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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