Rabbit Anti-KIF23 Recombinant Antibody (CBFYM-0300) (CBMAB-M0365-FY)

Name: Rabbit Anti-KIF23 Recombinant Antibody (CBFYM-0300)
SKU: CBMAB-M0365-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYM-0300

Application

WB, IF

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1.451 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Kinesin Family Member 23

Introduction

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants.

Entrez Gene ID

Human	9493
Mouse	71819
Rat	315740

UniProt ID

Human	Q02241
Mouse	E9Q5G3
Rat	D4AAG4

Alternative Names

Kinesin Family Member 23; Kinesin-Like 5 (Mitotic Kinesin-Like Protein 1); KNSL5; MKLP1; Mitotic Kinesin-Like Protein 1; Kinesin-Like Protein KIF23; Kinesin-Like Protein 5; MKLP-1; CHO1

Function

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Biological Process

Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic spindle elongationManual Assertion Based On ExperimentTAS:ProtInc
Mitotic spindle midzone assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring. Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

PTM

Ubiquitinated. Deubiquitinated by USP8/UBPY.

Xu, Q., Li, X., Li, Y., Yu, J., & Yang, A. (2023). Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/β-catenin pathway. Functional & Integrative Genomics, 23(2), 154.

Li, Z., Yang, H. Y., Zhang, X. L., Zhang, X., Huang, Y. Z., Dai, X. Y., ... & Ding, Q. (2022). Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway. Journal of Experimental & Clinical Cancer Research, 41(1), 168.

He, X., Wang, J., Zhou, R., Yu, S., Jiang, J., & Zhou, Q. (2022). Kinesin family member 23 exerts a protumor function in breast cancer via stimulation of the Wnt/β-catenin pathway. Toxicology and Applied Pharmacology, 435, 115834.

Shen, E., Zhang, J., & Lu, Y. (2022). DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23). Bioengineered, 13(1), 1103-1114.

Yao, D. W., Qun, S. O. N. G., & He, X. Z. (2021). Kinesin family member 23 (KIF23) contributes to the progression of bladder cancer cells in vitro and in vivo. Neoplasma, 68(2).

Li, X., Huang, W., Huang, W., Wei, T., Zhu, W., Chen, G., & Zhang, J. (2020). Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. American Journal of Translational Research, 12(5), 1614.

Gao, C. T., Ren, J., Yu, J., Li, S. N., Guo, X. F., & Zhou, Y. Z. (2020). KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target. Annals of translational medicine, 8(21).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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