KLHL6

This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.

kelch-like 6

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

B cell receptor signaling pathwayIEA:Ensembl
Germinal center formationIEA:Ensembl
Response to bacteriumIEA:Ensembl