Rabbit Anti-KLHL6 Recombinant Antibody (CBLY1-120) (CBMAB-K1202-LY)

Name: Rabbit Anti-KLHL6 Recombinant Antibody (CBLY1-120)
SKU: CBMAB-K1202-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBLY1-120

Antibody Isotype

IgG

Application

WB, IP, ICC/IF

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

2.546 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

kelch-like 6

Introduction

This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Entrez Gene ID

89857

UniProt ID

Q8WZ60

Alternative Names

Kelch Like Family Member 6; Kelch-Like 6 (Drosophila); Kelch-Like Protein KLHL6;

Function

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Biological Process

B cell receptor signaling pathwayIEA:Ensembl
Germinal center formationIEA:Ensembl
Response to bacteriumIEA:Ensembl

More Infomation

References

Han, L., Chen, Z., & Sun, L. (2023). Expression, purification, and microscopic characterization of the tumor suppressor KLHL6. Protein Expression and Purification, 106318.

Meriranta, L., Sorri, S., Zafar, S., Liu, X., Sahlberg, E., Dufva, O., ... & Leppa, S. (2022). Oncogenic Mutational Disruption of KLHL6 Dimers Fuels B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma. Blood, 140(Supplement 1), 5889-5890.

Zhao, D., Hou, F., Li, M., Qi, Y., Luo, N., & Wang, Y. (2021). A novel KLHL6/KLHL24 intergenic region-NTRK3 fusion in a patient with lung squamous cell carcinoma. Lung Cancer, 155, 193-195.

Choi, J., Zhou, N., & Busino, L. (2019). KLHL6 is a tumor suppressor gene in diffuse large B-cell lymphoma. Cell Cycle, 18(3), 249-256.

Choi, J., Lee, K., Ingvarsdottir, K., Bonasio, R., Saraf, A., Florens, L., ... & Busino, L. (2018). Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Nature cell biology, 20(5), 586-596.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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